{"product_id":"cosmedix-define-45ml","title":"Cosmedix Define Age-Defying Treatment 45g","description":"\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eRetinol cream with triple AHA complex for anti-aging\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eFor those exploring retinol, one difficult question often arises: how do you start wisely? The world of retinoids is overwhelming — concentration charts, prescription versus over-the-counter formulas, retinol versus retinal versus retinyl esters. Starting too weak misses results. Starting too strong leads to weeks of flaking and sensitivity. Modern science has therefore developed 'gateway formulas': products with chirally correct retinol in moderate concentration, combined with additional exfoliating acids, which work visibly and are comfortably tolerable.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eCosmedix Define is exactly such a product. The cream combines 2% AGP Retinol Complex with a triple alpha hydroxy acid mix of 5% lactic acid, 1% malic acid, and 1% tartaric acid — a combination that enhances the effect of retinol while refining skin texture. Supplemented with resveratrol ferment extract, olive oil, and witch hazel for antioxidant protection and soothing. The official entry route of Cosmedix into retinol action, suitable for all skin types and especially loved by those seeking visible results without the irritation of classic retinol formulas.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.375rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eReduces the visibility of fine lines and wrinkles\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eEvens skin tone and fades pigmentation spots\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eRefines skin texture with a triple hydroxy acid complex\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eHydrates during retinol action with olive oil and aloe\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSuitable as an entry product for a Cosmedix retinol routine\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eGluten-free — even for severe gluten sensitivity or Dermatitis Herpetiformis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eActive ingredients\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003e2% AGP Retinol Complex:\u003c\/strong\u003e The signature ingredient of the Cosmedix Define and Refine line. AGP stands for Amino-Acid Glycine-PCA — a complex where retinol is combined with chirally correct amino acids. The ingredient is micro-encapsulated, meaning retinol is released gradually into the skin, causing less irritation than classic retinol. The 2% concentration in Define makes it the ideal starting point before possibly moving on to Refine 4% or higher concentrations.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003e5% L-Lactic Acid:\u003c\/strong\u003e An alpha hydroxy acid in its chirally correct L-form — the form the body naturally uses and best recognizes. Exfoliates the skin surface and uniquely also hydrates, unlike many other AHAs. At 5% concentration, it visibly refines skin texture without causing pronounced sensitivity.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003e1% L-Malic Acid:\u003c\/strong\u003e An AHA from apples that works on skin texture and provides gentle exfoliation. Helps reduce the appearance of fine lines and contributes to a more even complexion. Works synergistically with lactic acid for a broader spectrum of exfoliating effects.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003e1% L-Tartaric Acid:\u003c\/strong\u003e An AHA from grapes that helps regulate the formula's pH balance and supports exfoliating action. The combination of lactic acid, malic acid, and tartaric acid is the \"triple hydroxy acid cocktail\" that sets Define apart from simpler retinol creams.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eResveratrol Ferment extract and Resveratrol Dimethyl Ether:\u003c\/strong\u003e Two forms of resveratrol — the famous antioxidant from red wine — that complement each other's effects. Protect the skin against photoaging and environmental damage that breaks down collagen and elastin.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eWitch Hazel water:\u003c\/strong\u003e A natural astringent ingredient that gently refines pores, soothes mild sensitivity, and helps control excess sebum. A valuable addition for combination skin seeking brightening without dryness.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eOlive oil (Olea Europaea):\u003c\/strong\u003e Rich in oleic acid and polyphenols. Hydrates and softens the skin during retinol action, helping to prevent dryness or sensitivity.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eL-Proline:\u003c\/strong\u003e An amino acid that forms a building block for collagen — the structural protein that keeps skin firmer and smoother. Supports the effect of retinol on skin firmness.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGalactoarabinan:\u003c\/strong\u003e A polysaccharide from larch tree with clinically studied hydrating and skin-softening properties. Reduces trans-epidermal water loss (TEWL) and helps keep the skin supple during treatment.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eAloe vera, allantoin, and L-bisabolol:\u003c\/strong\u003e Three soothing ingredients that calm the skin during the exfoliating process. Especially valuable during the first weeks of retinol use.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003ePichia ferment, ylang-ylang, and grapefruit peel oil:\u003c\/strong\u003e Botanical and fermented ingredients that nourish the skin and give the formula a pleasant, light scent.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eHow to use it\u003c\/h3\u003e\n\u003col class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-decimal flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eUse Define only in the evening — always wear SPF during the day\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eCleanse and tone the skin according to the regular evening routine\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eStart with application two to four times per week — not daily at first\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eApply a small amount to cleansed, dried skin\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eGently spread over face and neck, avoid direct contact with eyes and corners of the mouth\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eFollow with a hydrating moisturizer if desired for extra comfort\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eBuild up gradually as the skin tolerates it — some users stay at two to four times per week, others go daily\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eGive the skin 4 to 8 weeks to get used to retinol — slight flaking is normal\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eSuitable for\u003c\/h3\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eFor those who want to get acquainted with retinol effects\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eFirst signs of aging and visible fine lines\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eMature skin with deeper wrinkles and loss of firmness\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003ePigmentation spots and post-acne discoloration\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eAll skin types — especially suitable for dry and sensitive skin that poorly tolerates classic retinol\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eNot suitable during pregnancy or breastfeeding\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eFrequently asked questions\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eWhat is the difference between Define and Refine?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eBoth contain the AGP Retinol Complex, but for different skin types and concentrations. Define works with 2% AGP Complex and additionally contains a triple hydroxy acid mix (lactic acid, malic acid, tartaric acid) — suitable for all skin types as an introduction, with an emphasis on anti-aging for mature or dry skin. Refine works with 4% AGP Complex without the extra hydroxy acids — stronger and more targeted for oily, combination, or blemish-prone skin that needs exfoliation. For those new to retinol: start with Define. For those with acne tendency: choose Refine.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eWhat is the difference between Define and Serum 16?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eTwo very different retinol products. Define is a rich cream with 2% AGP Complex plus additional AHAs — suitable for dry and mature skin as an entry product. Serum 16 is a lightweight serum with 16% LG-Retinex (a combination of retinol and retinal) — suitable for those already experienced with retinol and seeking a more intensive result without the irritation of classic high concentration. Serum 16 is stronger but milder than its number suggests thanks to micro-encapsulation.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eWhen will I see the first results from Define?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThe first improvement in skin texture and visible smoothing usually appears after 4 to 6 weeks — retinol works on the natural 28-day cell renewal cycle. For structural reduction of fine lines, wrinkles, and pigmentation spots, consistent use for 8 to 12 weeks is needed. The skin may go through an adjustment phase with light flaking in the first weeks — this is normal and will disappear on its own.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eCan I use Define during pregnancy or breastfeeding?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNo. Retinol is not recommended during either period due to possible risks to the child's development. Alternatives for anti-aging during pregnancy are available, such as a peptide serum (Affirm or Cell ID), a combination of niacinamide and vitamin C (BrillianCy), or a bakuchiol formula from brands that offer it. Always consult your midwife or skin therapist.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eCan I combine Define with vitamin C or other acids?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNot on the same evening. Do not combine Define with other AHAs or BHAs in the same routine — Define already contains a triple AHA complex. Classic routine: vitamin C (Simply Brilliant or BrillianCy) and SPF in the morning, Define in the evening at the desired frequency. Or alternate Define and another active serum on different evenings of the week.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eWhat should I do if my skin flakes or becomes irritated?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eLight flaking and mild redness are normal in the first weeks — a sign that the skin is getting used to retinol. In that case, reduce the frequency to once a week and use a rich moisturizing cream like Emulsion or Humidify. Optionally, add C.P.R. Skin Recovery Serum as a soothing layer underneath. If irritation persists after three weeks, pause for a week and restart with a gentler buildup.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eHow long does a 45g tube last?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eWhen used as directed (starting two to four times per week), a 45g tube typically lasts three to four months. For those who switch to daily use, it lasts about two to three months. This makes a tube well suited for a complete retinol buildup phase of several months.\u003c\/p\u003e","brand":"Cosmedix","offers":[{"title":"Default Title","offer_id":56635794817355,"sku":null,"price":100.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1009\/6908\/7307\/files\/513de06b2946c9327007a7fc5f83f2cf48f0a7c0.jpg?v=1779224966","url":"https:\/\/webshop.glamskin.nl\/en\/products\/cosmedix-define-45ml","provider":"Glam Skin Webshop","version":"1.0","type":"link"}