{"product_id":"cosmedix-refine-15ml","title":"Cosmedix Refine Refinishing Treatment 15ml","description":"\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eRetinol treatment with 4% AGP Complex for smoother skin\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eStarting a serious retinol routine is not an easy choice. Too weak and results are lacking; too strong and the skin reacts with redness, flaking, and weeks of downtime. Recent vitamin A science has developed a middle ground: chirally correct retinol forms combined with amino acids that are both visibly effective and better tolerated by the skin.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eCosmedix Refine is the entry product of the well-known Refine line, with 4% AGP Retinol Complex including 0.5% pure retinol. The formula is specifically designed for those who want to experience serious retinol effects — not too mild to miss results, not too strong to overload the skin. Amino acids support the skin barrier during exfoliation, allowing even combination or blemish-prone skin to tolerate the treatment well. The ideal preparation for the stronger Refine Plus and Refine RX from the same line.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.375rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eReduces the visibility of fine lines and wrinkles\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eRefines the appearance of enlarged pores\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eReduces blemishes and blackheads through improved exfoliation\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eEvens skin texture thanks to cell renewal\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSupports the skin barrier with amino acids during treatment\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSuitable as an entry product of the Cosmedix Refine line\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eActive ingredients\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003e4% AGP Retinol Complex (with 0.5% Retinol):\u003c\/strong\u003e An exclusive Cosmedix formulation combining pure retinol with amino acids (Amino-Acid Glycine-PCA, hence AGP). This combination is specifically developed for oily, combination, or blemish-prone skin that requires a stronger retinol effect. By using chirally correct L-forms of the amino acids, the formula is efficient and relatively mild for the concentration level.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRetinyl Acetate:\u003c\/strong\u003e A form of vitamin A that is converted in the skin to retinol and then retinoic acid — the active form. Works complementarily to the direct retinol effect and provides a sustained release of vitamin A in the skin, improving tolerability.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSodium PCA and Sodium Lactate:\u003c\/strong\u003e Two natural humectants found in the skin as part of the Natural Moisturizing Factor (NMF). Compensate for potential moisture loss caused by retinol and keep the skin supple during active treatment.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eL-Hydroxyproline and L-Proline:\u003c\/strong\u003e Two amino acids that form building blocks for collagen — the structural protein that keeps skin firmer and smoother. Support the action of retinol on skin structure by nourishing the natural production of collagen.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSqualane:\u003c\/strong\u003e A biomimetic lipid identical to a natural component of the skin’s sebum. Strengthens the skin barrier and prevents moisture loss — a targeted supplement to retinol’s effect, as retinol can temporarily weaken the barrier.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSodium Hyaluronate:\u003c\/strong\u003e The salt form of hyaluronic acid that attracts and retains moisture in the skin. Helps maintain hydration during the exfoliation process triggered by retinol.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eD-Glucuronolactone:\u003c\/strong\u003e A polyhydroxy acid that gently exfoliates and enhances retinol’s effect. Milder than classic AHAs or BHAs and suitable for sensitive skin.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGalactoarabinan:\u003c\/strong\u003e A polysaccharide from larch tree with clinically studied hydrating and skin-soothing properties. Reduces trans-epidermal water loss (TEWL) and helps keep the skin supple during treatment.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eHamamelis water (Witch Hazel):\u003c\/strong\u003e A natural astringent toner base that slightly refines pores and helps control excess sebum. Works synergistically with retinol’s pore-refining effect.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eHow to use it\u003c\/h3\u003e\n\u003col class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-decimal flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eUse Refine only in the evening — always wear SPF during the day\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eCleanse and tone the skin according to the regular evening routine\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eStart applying once every three nights during the first two weeks\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eApply a coin-sized amount to cleansed, dry skin\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eGradually build up to once every two nights, then daily\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eOptionally finish with a hydrating moisturizer for extra comfort\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eGive the skin 4 to 8 weeks to get used to retinol — small flakes are normal\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eAfter 60-90 days of consistent use, ready to possibly switch to Refine Plus 8%\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eSuitable for\u003c\/h3\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eOily, combination, and blemished skin needing refinishing\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eVisible enlarged pores and uneven skin texture\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eFirst signs of aging and visible fine lines\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eWho is introduced to the Cosmedix Refine line\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003ePigmentation spots and post-acne discoloration\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eNot suitable during pregnancy or breastfeeding\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eFrequently asked questions\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eWhat is the difference between Refine, Refine Plus, and Refine RX?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThree steps of the same retinol line with increasing concentration. Refine contains 4% AGP Complex (0.5% retinol) — the entry-level product. Refine Plus contains 8% AGP Complex (1% retinol) — double the potency for those who have consistently used Refine for 60-90 days. Refine RX with 12% AGP Complex (1.5% retinol) is the most concentrated option, suitable for those who have completed the full build-up process. The structured build-up is intentional — starting directly with Refine RX overloads most skin types.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eWhat is the difference between Refine and Serum 16?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eTwo different retinol technologies for different skin types. Serum 16 uses 16% LG-Retinex (micro-encapsulated retinol+retinal) and is suitable for dry and sensitive skin that poorly tolerates classic retinol. Refine uses the AGP Complex with chirally correct retinol and is formulated for oily, combination, or impure skin that needs exfoliation alongside anti-aging effects. When in doubt: for anti-aging on dry skin choose Serum 16, for impure skin choose Refine.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eWhen will I see the first results from Refine?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThe first refresh in skin texture is usually visible after 2 to 4 weeks. For structural improvement of fine lines, pores, and skin tone, daily use for 8 to 12 weeks is needed. The skin may go through a 'purging phase' in the first weeks where underlying impurities come to the surface faster — this is normal and lasts 4 to 6 weeks.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eCan I combine Refine with other active ingredients like vitamin C or acids?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNot on the same evening. Do not combine Refine with AHA, BHA, or PHA acids or strong vitamin C formulas in the same routine — that overloads the skin. Classic schedule: Refine in the evening, vitamin C (Simply Brilliant or Pure C Mixing Crystals) and SPF in the morning. Or alternate active evening serums on different days.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eCan I use Refine during pregnancy or breastfeeding?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNo. Retinol is not recommended during either period due to possible risks to the child's development. Alternatives are available for care during pregnancy, such as a peptide serum (Affirm or Cell ID), a formula with niacinamide, or a combination with bakuchiol from brands that offer it. Always consult your midwife or skin therapist.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eWhat should I do if my skin flakes or becomes irritated?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eLight flaking and mild redness are normal in the first weeks — a sign that the skin is getting used to retinol. In that case, reduce the frequency to once every three nights and use a rich moisturizing cream or add C.P.R. Skin Recovery Serum as a soothing layer. If irritation persists after three weeks, pause for a week and restart with a gentler buildup.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eHow long does a 15ml bottle last?\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eWhen used according to the schedule (starting every three nights, gradually building up to every evening), a 15ml bottle lasts about two to three months. For most users, this is more than enough to assess the effect and possibly switch to Refine Plus after 60-90 days.\u003c\/p\u003e","brand":"Cosmedix","offers":[{"title":"Default Title","offer_id":56635831419211,"sku":null,"price":91.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1009\/6908\/7307\/files\/b935de8fbc25646460e858ed9294a3edce3c8289.jpg?v=1779224305","url":"https:\/\/webshop.glamskin.nl\/en\/products\/cosmedix-refine-15ml","provider":"Glam Skin Webshop","version":"1.0","type":"link"}